| Hennessey | Lack of match fitness - 75% chance of playing | Crystal Palace | Goalkeeper |
| Rodák | Hand injury - 25% chance of playing | Fulham | Goalkeeper |
| de Gea | Personal Reasons - Expected back 03 Apr | Man Utd | Goalkeeper |
| Randolph | Thigh injury - 75% chance of playing | West Ham | Goalkeeper |
| Kelleher | Knock - 75% chance of playing | Liverpool | Goalkeeper |
| Olsen | Knock - 75% chance of playing | Everton | Goalkeeper |
| Hause | Foot injury - 25% chance of playing | Aston Villa | Defender |
| Webster | Ankle injury - Expected back 03 Apr | Brighton | Defender |
| Lamptey | Hamstring injury - Unknown return date | Brighton | Defender |
| Taylor | Leg injury - 75% chance of playing | Burnley | Defender |
| Sakho | Thigh injury - Unknown return date | Crystal Palace | Defender |
| Tomkins | Eye Injury - Unknown return date | Crystal Palace | Defender |
| Ferguson | Lack of match fitness - Expected back 03 Apr | Crystal Palace | Defender |
| Mitchell | Muscle injury - Expected back 03 Apr | Crystal Palace | Defender |
| Coleman | Knock - 75% chance of playing | Everton | Defender |
| Mina | Calf injury - Expected back 03 Apr | Everton | Defender |
| Morgan | Back injury - Expected back 03 Apr | Leicester | Defender |
| Evans | Calf injury - 75% chance of playing | Leicester | Defender |
| Justin | Knee injury - Unknown return date | Leicester | Defender |
| Matip | Ankle injury - Expected back 01 Jul | Liverpool | Defender |
| van Dijk | Knee injury - Unknown return date | Liverpool | Defender |
| Gomez | Knee injury - Unknown return date | Liverpool | Defender |
| Schär | Knee injury - Expected back 10 Apr | Newcastle | Defender |
| Basham | Hamstring injury - 25% chance of playing | Sheffield Utd | Defender |
| Jack Robinson | Knock - Unknown return date | Sheffield Utd | Defender |
| Egan | Toe Injury - Expected back 17 Apr | Sheffield Utd | Defender |
| O'Connell | Knee injury - Unknown return date | Sheffield Utd | Defender |
| Aurier | Calf injury - 75% chance of playing | Spurs | Defender |
| Gibbs | Neck - Unknown return date | West Brom | Defender |
| Ogbonna | Ankle injury - Unknown return date | West Ham | Defender |
| Fredericks | Groin Injury - 50% chance of playing | West Ham | Defender |
| Masuaku | Knee injury - Unknown return date | West Ham | Defender |
| Koch | Knee injury - 25% chance of playing | Leeds | Defender |
| Cash | Hamstring injury - 25% chance of playing | Aston Villa | Defender |
| Marçal | Thigh injury - 25% chance of playing | Wolves | Defender |
| Clyne | Muscle injury - Expected back 13 Mar | Crystal Palace | Defender |
| Kabak | Knock - 50% chance of playing | Liverpool | Defender |
| Smith Rowe | Hip injury - 75% chance of playing | Arsenal | Midfielder |
| Grealish | Leg injury - 25% chance of playing | Aston Villa | Midfielder |
| El Ghazi | Toe Injury - 75% chance of playing | Aston Villa | Midfielder |
| March | Knee injury - Expected back 29 May | Brighton | Midfielder |
| Cork | Hamstring injury - 75% chance of playing | Burnley | Midfielder |
| McArthur | Calf injury - Expected back 03 Apr | Crystal Palace | Midfielder |
| McCarthy | Groin Injury - Expected back 03 Apr | Crystal Palace | Midfielder |
| Walcott | Muscle injury - Expected back 03 Apr | Southampton | Midfielder |
| Delph | Tendon Injury - 25% chance of playing | Everton | Midfielder |
| Gbamin | Achilles injury - Expected back 03 Apr | Everton | Midfielder |
| Cairney | Knee injury - Unknown return date | Fulham | Midfielder |
| Praet | Muscle injury - 25% chance of playing | Leicester | Midfielder |
| Pérez | Knee injury - 75% chance of playing | Leicester | Midfielder |
| Maddison | Hip injury - Unknown return date | Leicester | Midfielder |
| Barnes | Knee injury - Expected back 10 Apr | Leicester | Midfielder |
| Forshaw | Hip injury - Unknown return date | Leeds | Midfielder |
| Shackleton | Hip injury - 50% chance of playing | Leeds | Midfielder |
| Henderson | Groin Injury - Expected back 03 Apr | Liverpool | Midfielder |
| Mata | Muscle injury - Expected back 14 Mar | Man Utd | Midfielder |
| Pogba | Thigh injury - 25% chance of playing | Man Utd | Midfielder |
| Rashford | Ankle injury - 75% chance of playing | Man Utd | Midfielder |
| Saint-Maximin | Groin Injury - Expected back 03 Apr | Newcastle | Midfielder |
| Almirón | Knee injury - Expected back 03 Apr | Newcastle | Midfielder |
| Berge | Hamstring injury - Expected back 03 Apr | Sheffield Utd | Midfielder |
| Oriol Romeu | Ankle injury - Unknown return date | Southampton | Midfielder |
| Smallbone | Knee injury - Unknown return date | Southampton | Midfielder |
| Lo Celso | Lack of match fitness - 75% chance of playing | Spurs | Midfielder |
| Yarmolenko | Knee injury - Unknown return date | West Ham | Midfielder |
| Podence | Muscle injury - 25% chance of playing | Wolves | Midfielder |
| van de Beek | Lack of match fitness - 75% chance of playing | Man Utd | Midfielder |
| Rodríguez | Knock - 75% chance of playing | Everton | Midfielder |
| Doucouré | Foot injury - Expected back 03 Apr | Everton | Midfielder |
| Ünder | Knock - 25% chance of playing | Leicester | Midfielder |
| Wesley | Lack of match fitness - 25% chance of playing | Aston Villa | Forward |
| Andone | Knee injury - Unknown return date | Brighton | Forward |
| Connolly | Back injury - 75% chance of playing | Brighton | Forward |
| Barnes | Thigh injury - 25% chance of playing | Burnley | Forward |
| Abraham | Ankle injury - 75% chance of playing | Chelsea | Forward |
| Firmino | Knock - 75% chance of playing | Liverpool | Forward |
| Ings | Muscle injury - Expected back 03 Apr | Southampton | Forward |
| Obafemi | Muscle injury - Unknown return date | Southampton | Forward |
| Jiménez | Head injury - Unknown return date | Wolves | Forward |
| Wilson | Hamstring injury - Expected back 20 Mar | Newcastle | Forward |
| Cavani | Knock - 75% chance of playing | Man Utd | Forward |
