| Dubravka | Foot injury - 25% chance of playing | Newcastle | Goalkeeper |
| Scherpen | Ankle injury - Unknown return date | Burnley | Goalkeeper |
| Gabriel | Knee injury - Unknown return date | Arsenal | Defender |
| Guilbert | Knock - 75% chance of playing | Aston Villa | Defender |
| Burn | Knee injury - Unknown return date | Burnley | Defender |
| Lamptey | Hamstring injury - Expected back 11 Sep | Burnley | Defender |
| Long | Achilles injury - Unknown return date | Chelsea | Defender |
| Ferguson | Achilles injury - Expected back 27 Nov | Everton | Defender |
| Llorente | Knock - Expected back 28 Aug | Leeds | Defender |
| Justin | Knee injury - Unknown return date | Leicester | Defender |
| Fofana | Leg injury - Unknown return date | Leicester | Defender |
| Robertson | Ankle injury - Expected back 12 Sep | Liverpool | Defender |
| Evans | Foot injury - Expected back 11 Sep | Leicester | Defender |
| Castagne | Lack of match fitness - 75% chance of playing | Leicester | Defender |
| Telles | Ankle injury - Expected back 11 Sep | Man Utd | Defender |
| Dummett | Calf injury - 50% chance of playing | Newcastle | Defender |
| Byram | Hamstring injury - 25% chance of playing | Sheffield Utd | Defender |
| Ogbonna | Hamstring injury - 25% chance of playing | West Ham | Defender |
| Masuaku | Lack of match fitness - 75% chance of playing | West Ham | Defender |
| Boly | Hamstring injury - 25% chance of playing | Wolves | Defender |
| Jonny | Knee injury - Unknown return date | Wolves | Defender |
| Mosquera | Hamstring injury - 25% chance of playing | Wolves | Defender |
| Romero | Knee injury - 75% chance of playing | Spurs | Defender |
| Partey | Ankle injury - Expected back 28 Aug | Arsenal | Midfielder |
| Sanson | Knee injury - 25% chance of playing | Aston Villa | Midfielder |
| Trézéguet | Knee injury - Unknown return date | Aston Villa | Midfielder |
| Buendía | Hip injury - 75% chance of playing | Aston Villa | Midfielder |
| Dasilva | Hip injury - Unknown return date | Brighton | Midfielder |
| Jensen | Lack of match fitness - Expected back 21 Aug | Brighton | Midfielder |
| Stephens | Ankle injury - Unknown return date | Chelsea | Midfielder |
| Ziyech | Shoulder injury - 25% chance of playing | Crystal Palace | Midfielder |
| Eze | Achilles injury - Unknown return date | Everton | Midfielder |
| Jones | Head injury - Expected back 21 Aug | Liverpool | Midfielder |
| De Bruyne | Ankle injury - 25% chance of playing | Man City | Midfielder |
| Foden | Foot injury - Expected back 11 Sep | Man City | Midfielder |
| Rashford | Shoulder injury - 25% chance of playing | Man Utd | Midfielder |
| Cantwell | Knock - 75% chance of playing | Sheffield Utd | Midfielder |
| Smallbone | Knee injury - Unknown return date | Southampton | Midfielder |
| Chalobah | Illness - Expected back 21 Aug | West Brom | Midfielder |
| Podence | Groin Injury - Unknown return date | Wolves | Midfielder |
| Neto | Knee injury - Unknown return date | Wolves | Midfielder |
| Olise | Back injury - 25% chance of playing | Everton | Midfielder |
| Nketiah | Ankle injury - Expected back 11 Sep | Arsenal | Forward |
| Watkins | Muscle injury - 75% chance of playing | Aston Villa | Forward |
| Davis | Knock - 25% chance of playing | Aston Villa | Forward |
| Calvert-Lewin | Knock - 75% chance of playing | Fulham | Forward |
| João Pedro | Knee injury - Unknown return date | West Brom | Forward |
| Welbeck | Hamstring injury - Expected back 11 Sep | Burnley | Forward |
| King | Groin Injury - Expected back 21 Aug | West Brom | Forward |
